Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Uwaya DO
Nigeria
Research Article
Evaluation of the Anti-asthmatic and Antitussive Effects of Aqueous Leaf Extract of Ocimum gratissimum in Rodents
Author(s): Ozolua RI, Umuso DI, Uwaya DO, Modugu AA, Oghuvwu SO and Olomu JMOzolua RI, Umuso DI, Uwaya DO, Modugu AA, Oghuvwu SO and Olomu JM
Background: Ocimum gratissimum Linn (Lamiaceae) is an aromatic plant popular for it culinary uses. The aqueous leaf extract is used in ethnomedicine for the treatment of various diseases including asthma and cough. The purpose of this study was to evaluate the anti-asthmatic, antitussive and muco-suppressant effects of the aqueous leaf extract (OGE) in rodent species.
Methods: Ovalbumin-sensitized guinea pigs were exposed to 0.2% histamine aerosol in a glass chamber. Latency to preconvulsive dyspnea (PCD), tracheal fluid volume and viscosity were measured. For the antitussive screening, guinea pigs were exposed to 7.5% citric acid aerosol in a glass chamber and the bouts of cough pre and post-acute exposure were recorded. Mucus expectoration was estimated in mice after seven-day treatment with OGE.
Results: Latency.. View More»
DOI:
10.4172/2167-0412.1000235