Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
ISSN: 2167-0412
Thomas Efferth
Department of Pharmaceutical Biology,
Staudinger Weg 5, 55128 Mainz
Germany
Review Article
Targeting Angiogenesis By Phytochemicals
Author(s): Onat Kadioglu, Ean Jeong Seo and Thomas EfferthOnat Kadioglu, Ean Jeong Seo and Thomas Efferth
Cancer is a major cause of death worldwide and angiogenesis is critical in cancer progression. Development of new blood vessels and nutrition of tumor cells are heavily dependent on angiogenesis. Thus, angiogenesis inhibition might be a promising approach for anticancer therapy. Anti-angiogenic small molecule and phytochemicals as a cancer treatment approach are focused in these main points; modes of action, adverse effects, mechanisms of resistance and new developments. Treatment with anti-angiogenic compounds might be advantageous over conventional chemotherapy due to the fact that those compounds mainly act on endothelial cells, which are genetically more stable and homogenous compared to tumor cells and they show lower susceptibility to acquired drug resistance (ADR). Targeting the VEGF (vascular endothelial growth factor) signalling pathway with synthetic small molecules inhibiti.. View More»
DOI:
10.4172/2167-0412.1000134