Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Saad Sabbar Dahham
EMAN Research and Testing Laboratory, School of Pharmaceutical Sciences,
11800 Penang
Malaysia
Research Article
In Vitro Anti-Cancer and Anti-Angiogenic Activity of Essential Oils Extracts from Agarwood (Aquilaria crassna)
Author(s): Saad Sabbar Dahham, Yasser M Tabana, Doblin Sandai, Mowaffaq Adam Ahmed and Amin M Shah Abdul MajidSaad Sabbar Dahham, Yasser M Tabana, Doblin Sandai, Mowaffaq Adam Ahmed and Amin M Shah Abdul Majid
Aquilaria crassna (agarwood) has been used in traditional Asian medicine to treat vomiting, rheumatism, asthma, cough and inflammation. Despite the wide range of ethno-pharmacological use of agarwood, its anti-angiogenic effect has not previously been evaluated through systematic studies. Therefore, the aim of this study was to prepare essential oils extracts from the stem bark of A. crassna native to Malaysia, and determine their anti-proliferative and anti-angiogenic activities. Stem bark samples were extracted with 80% ethanol and hydrodistillation methods. The resulting essential oils from both extraction approaches were subjected for cytotoxic activity using four cancer cell lines and one normal cell line. Hydrodistilled essential oils displayed significant cytotoxic effect against HCT 116 cells with the lowest IC50 value calculated (28.0 ± 1.5 μg/mL). Furthermore, we h.. View More»
DOI:
10.4172/2167-0412.1000256