6α-Acetoxy-7α-Hydroxy-Vouacapan Isolated from Pterodon pubescens Benth. Fruit’s with Selective Activity against Prostate Cancer Cell Line: Artifact or Natural Product?
Author(s): Lloret FC, Santos CCJ, Medina LS, Queiroz NCA, Sousa IMO, Ruiz ALTG, Carvalho JE and Foglio MALloret FC, Santos CCJ, Medina LS, Queiroz NCA, Sousa IMO, Ruiz ALTG, Carvalho JE and Foglio MA
Challenges encountered in standardization of plant-derived drugs involves the determination of many parameters that implies quality control methods throughout the entire process from growing conditions to the final product. This study highlights the complexity of factors involved in the production of secondary metabolites in plants. Compound 6α-acetoxy-7α-hydroxy-vouacapan Isolated from Pterodon pubescens Benth. (Fabeacea) fruit dichloromethane extract, with in vitro cytotoxic selectivity on human prostate cancer cell line was investigated to determine if the compound is an artifact produced overtime on plant storage or is characteristic of plant genotype. The chemical composition of samples from São Carlos (São Paulo, Brazil) and Ponto Chique (Minas Gerais, Brazil) were monitored monthly during one year for geranylgeraniol, 6α-acetoxy-7α-hydroxy-.. View More»