Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Ratnamala S Bendre
School of Chemical Sciences,
Jalgaon, Maharashtra
India
Commentary
Comparative Anti-Proliferative Studies of Natural Phenolic
Monoterpenoids on Human Malignant Tumour Cells
Author(s): Jamatsing D Rajput, Suresh D Bagul, Samina Tadavi and Ratnamala S BendreJamatsing D Rajput, Suresh D Bagul, Samina Tadavi and Ratnamala S Bendre
In present study we report prominent effect of carvacrol (5-isopropyl-2-methyl phenol), thymol (2-isopropyl-5- methyl phenol) and eugenol (4 allyl-2-methoxyphenol) on Human melanoma cells. These three compounds were screened for Anti-proliferative test by using Sulforhodamine B (SRB) assay. For this investigation we used human breast melanoma cell line MCF-7, human skin melanoma cell line SK-MEL-2, human colon melanoma cell line HCT-15 and human pancreatic melanoma cell line MIAPaCa-2. Carvacrol was identified as most potent molecule with low GI50 value as 0.1 μL for selected human cancer cell lines; which is comparatively equal to standard drug 14 Adriamycin (ADR). Thymol and Eugenol also exhibited remarkable GI50 for human cancer cell 15 lines.
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DOI:
10.4172/2167-0412.1000279