Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Oghuvwu SO
Nigeria
Research Article
Extract of Garcinia kola Seed has Antitussive Effect and Attenuates Hypercholesterolemia in Rodents
Author(s): Ozolua RI, Saba AO, Uwaya DO, Abelega N and Oghuvwu SOOzolua RI, Saba AO, Uwaya DO, Abelega N and Oghuvwu SO
Background: The seeds of Garcinia kola Heckel (Guttiferrae) are widely eaten in West Africa for cultural and ethnomedicinal reasons including cough suppression and body fat reduction. We prepared a 70% ethanol extract and designed experiments to investigate the antitussive and anti-hypercholesterolemic effects. Methods: For the antitussive investigations, guinea pigs were exposed to 7.5% citric acid aerosol in a chamber and cough bouts were counted after acute doses of the extract. Mucus expectoration was evaluated in mice after administering the extract for seven days by measuring the concentration of phenol red dye released from mouse trachea. Hypercholesterolemia was induced and doses of the extract were administered for 14 days. Results: Single doses of 100, 200 and 400 mg/kg (p.o.) significantly (p<0.01) and dose-dependently suppressed cough bouts by 67, 78 and 92% respectivel.. View More»
DOI:
10.4172/2167-0412.1000232