Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
ISSN: 2167-0412
Nikolaos Papaioannou
Greece
Research Article
The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats
Author(s): Patsaki Anastasia, Job Tchoumtchoua, Christina Passali, Lelovas Pavlos, Stavros Kourkoulis, Nikolaos Papaioannou, Jean-Claude Mbanya, Dieudonné Njamen, Sofia Mitakou, Maria Halabalaki and Ismene DontasPatsaki Anastasia, Job Tchoumtchoua, Christina Passali, Lelovas Pavlos, Stavros Kourkoulis, Nikolaos Papaioannou, Jean-Claude Mbanya, Dieudonné Njamen, Sofia Mitakou, Maria Halabalaki and Ismene Dontas
Background: To assess the potential phytoestrogenic effect of Amphimas pterocarpoides plant extract on the ovariectomy (OVX) induced bone loss in rats. Methods: Thirty nine female (10 month old) Wistar rats were separated into Controls (n=11), OVX (n=13) and OVX+AP groups (n=15). Measurements of Bone Mineral Density (BMD) were performed at baseline, 3 and 6 months after ovariectomy. After 6 months treatment, the rats were euthanized and femurs were extracted. The biomechanical properties were evaluated using the 3-point bending test. Results: The percentage changes of the mean values of the proximal tibia BMD from baseline to 3 months for Control, OVX and OVX+AP group were 6.25%, -21.82% and - 12.73% whereas at 6 months they were 8.108%, -32.134% and -22.410% respectively. The 3-point bending test revealed that the maximal load before fracture and the mean values for stress significan.. View More»
DOI:
10.4172/2167-0412.1000269