Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Kaul SC
Indian Institute of Science,
Bangalore 560012
India
Research Article
3beta-Methoxy Derivation of Withaferin-a Attenuates its Anticancer
Potency: Bioinformatics and Molecular Evidences
Author(s): Huang C, Vaishnavi K, Kalra RS, Zhang Z, Sekar K, Kaul SC and Wadhwa RHuang C, Vaishnavi K, Kalra RS, Zhang Z, Sekar K, Kaul SC and Wadhwa R
Withaferin A (Wi-A), a potent anticancer withanolide extracted from Withania somnifera- a tropical medicinal plant, was earlier shown to activate p53 tumor suppressor and oxidative stress pathways in cancer cells causing either growth arrest or apoptosis. In view of the information that alkyl derivatives of several bioactive steroidal compounds exhibit improved stability and activity through mechanisms that have not been completely understood, we investigated the effect of Withaferin A and its methoxy-derivative (2,3-dihydro-3- methoxy-Withaferin A) on human cancer cells to analyze the molecular interactions and efficacy. Systematic bioinformatics and molecular experimental approaches comprising expression analysis and imaging techniques were employed to demonstrate the interactions of Withaferin A and 3β-methoxy Withaferin A with their molecular targets. We demonstrate that 3&be.. View More»
DOI:
10.4172/2167-0412.1000219