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Advancements in Genetic Engineering

Advancements in Genetic Engineering
Open Access

ISSN: 2169-0111

+44 1478 350008

Jian Li

Jian Li

Tanzania

Publications
  • Research Article
    Fusing Gene Interaction to Improve Disease Discrimination on Classification Analysis
    Author(s): Ji-Gang Zhang, Jian Li, Wenlong Tang and Hong-Wen DengJi-Gang Zhang, Jian Li, Wenlong Tang and Hong-Wen Deng

    It is usually observed that among genes there exist strong statistical interactions associated with diseases of public health importance. Gene interactions can potentially contribute to the improvement of disease classification accuracy. Especially when gene expression differs across different classes are not great enough, it is more important to take use of gene interactions for disease classification analyses. However, most gene selection algorithms in classification analyses merely focus on genes whose expression levels show differences across classes, and ignore the discriminatory information from gene interactions. In this study, we develop a two-stage algorithm that can take gene interaction into account during a gene selection procedure. Its biggest advantage is that it can take advantage of discriminatory information from gene interactions as well as gene expression dif.. View More»
    DOI: 10.4172/2169-0111.1000102

    Abstract PDF

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