ISSN: ISSN: 2329-6674
Current progress in computational structure based protein design is reviewed in the areas of methodology and applications. Applications include new approaches and successes in the design of specificity for protein folding,binding affinity and in the application of design technology to study and alter enzyme catalysis. Computational protein design continues to mature and advance.
Aprotein design cycle involving cycling between theory and experiment has led to recent advances in rational protein design.A reductionist approach in which protein positions are classified by their local environments has aided development of an appropriate energy expression.
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