ISSN: ISSN: 2329-6674
Protein engineering strategies aimed at constructing enzymes with improved activities, specificities and stabilities greatly benefit from in silico methods.Computational methods can be principally grouped into three main categories. They are bioinformatics, molecular modeling and de novo design.Computational enzyme design is a very promising area of research. The current computational design tools suffer from a serious limitation.
Protein engineering strategies aimed at constructing enzymes with novel or improved activities, specificities, and stabilities greatly benefit from in silico methods. Computational methods can be principally grouped into three main categories:bioinformatics; molecular modelling; and de novo design.Particularly de novo protein design is experiencing rapid development, resulting in more robust and reliable predictions.A recent trend in the field is to combine several computational approaches in an interactive manner and to complement them with structural analysis and directed evolution. A detailed investigation of designed catalysts provides valuable information on the structural basis of molecular recognition,biochemical catalysis, and natural protein evolution.
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Data Mining in Genomics & Proteomics Journal, Single Cell Biology journals, Genomic Medicine journals, Journal of Tissue Science & Engineering, Journal of Cheminformatics,Current Synthetic and Systems Biology, Clinical & Medical Genomics, Chemical Biology and Drug Design, Current Computer-Aided Drug Design, Current Pharmaceutical Design, International Journal of Computational Biology and Drug Design.