Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Abdirahman YA
Mogadishu
Somalia
Research Article
In-Vivo Anti-hyperglycemic Activity and Safety of The Aqueous Stem Bark
Extracts of Aloe secundiflora
Author(s): Abdirahman YA, Juma KK, Nyamai DW, Njagi JM, Agyirifo DS, Ngugi MP, Gathumbi PK, Ngeranwa JJN and Njagi ENMAbdirahman YA, Juma KK, Nyamai DW, Njagi JM, Agyirifo DS, Ngugi MP, Gathumbi PK, Ngeranwa JJN and Njagi ENM
Aloe secundiflora has been used traditionally to manage many diseases including diabetes, however, its antidiabetic activity and safety is not well evaluated. The aim of this study was to determine in vivo hypoglycemic activity and safety of the aqueous stem bark extracts of this plant in male swiss white albino mice. The antidiabetic activity was screened in alloxan induced diabetic mice using oral and intraperitoneal routes. The safety of the extract was studied in mice that were orally and intraperitoneally administered with 1 g/kg body weight of the extract daily for 28 days by recording changes in body and organ weights, hematological and biochemical parameters. Mineral composition was estimated using total reflection X-ray fluorescence system and atomic absorption spectrometry. Phytochemical composition was assessed using standard procedures. The extract showed significant and c.. View More»
DOI:
10.4172/2167-0412.S1-003