Journal of Down Syndrome & Chromosome Abnormalities

Journal of Down Syndrome & Chromosome Abnormalities
Open Access

ISSN: 2472-1115

+44 1223 790975

Yue-Fang Zhao

Yue-Fang Zhao

Bolivarian Rep. of Venezuela

  • Review Article
    The Role of Casein Kinase 1 in Meiosis
    Author(s): Yue-Fang Zhao and Cheng-Guang LiangYue-Fang Zhao and Cheng-Guang Liang

    The casein kinase 1 (CK1) belongs to the serine/threonine protein kinases. CK1 members, which commonly exist in all eukaryotes, are involved in the regulation of many cellular processes linked to cell cycle progression, spindledynamics, and chromosome segregation. Additionally, CK1 regulate key signaling pathways such as Wnt (Wingless/ Int-1), Hh (Hedgehog), and Hippo, known to be critically involved in tumor progression. Considering the importance of CK1 for accurate cell division and regulation of tumor suppressor functions, it is not surprising scientific effort has enormously increased. In mammals, CK1 regulate the transition from interphase to metaphase in mitosis. In budding yeast and fission yeast, CK1 phosphorylate Rec8 subunits of cohesin complex and regulate chromosome segregation in meiosis. During meiosis, two rounds of chromosome segregation after a single round of DNA re.. View More»
    DOI: 10.4172/2472-1115.1000106

    Abstract PDF

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