Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Yoshihiro Kobashi
Kawasaki Medical School,
577 Matsushima, Kurashiki, 701-0192
Japan
Research Article
Clinical Evaluation of IP-10 and MIG for the Diagnosis of Active Tuberculosis Disease
Author(s): Yoshihiro Kobashi, Keiji Mouri, Shigeki Kato and Mikio OkaYoshihiro Kobashi, Keiji Mouri, Shigeki Kato and Mikio Oka
Background: The aim of this study was to evaluate the clinical potential of IP-10 and MIG as biomarkers of tuberculosis (TB) infection adding a comparison with IGRAs (QFT and T-SPOT.TB).
Materials and Methods: The subjects consisted of 52 patients with active TB disease and 86 patients with non-TB disease. We measured two IGRAs using peripheral blood (PB), and IP-10 and MIG using the supernatant from whole blood stimulated with MTB (Mycobacterium tuberculosis)-specific antigens.
Results: In the patient group with active TB disease, while the positive response rates of QFT and T-SPOT.TB were 81% and 87%, that of IP-10 using the supernatant was 88% and that of MIG was 85%. In the patient group with non-TB disease, the positive response rate of QFT was 13%, and that of T-SPOT.TB was 14%, IP-10 using the supernatant wa.. View More»
DOI:
10.4172/2161-1068.1000185