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Mycobacterial Diseases

Mycobacterial Diseases
Open Access

ISSN: 2161-1068

Xiyuan Bai

Xiyuan Bai

Tanzania

Publications
  • Review Article
    Animal Models of Non-Tuberculous Mycobacterial Infections
    Author(s): Edward D. Chan, Xiyuan Bai, Diane J. Ordway and Deepshikha VermaEdward D. Chan, Xiyuan Bai, Diane J. Ordway and Deepshikha Verma

    The use of animal models has been essential in understanding the pathogenesis of and hosts immune response to tuberculosis, as well as testing potential antimicrobial compounds and vaccines. Experimental animals have also been used to study infections due to non-tuberculous mycobacteria (NTM). Because there are many different species of NTM capable of causing disease and they have varying degrees of virulence, developing animal models that are suitable for the diseases they cause isolated lung disease, skin and soft-tissue infections, and visceral extra pulmonary /disseminated disease is challenging. The goal of this review is to discuss the various animal models that have been used to study the pathogenesis of NTM infection as well as screening candidate antimicrobials, which are essential endeavors if better control of NTM infection is to be achieved. .. View More»
    DOI: 10.4172/2161-1068.1000216

    Abstract PDF

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