Family Medicine & Medical Science Research
Open Access
ISSN: 2327-4972
ISSN: 2327-4972
Suvi-Tuulia Hämäläinen
Faculty of Medicine and Life Sciences,
Tampere
Finland
Research Article
Intrahepatic Cholestasis of Pregnancy and Cancer: A Cohort Study
Author(s): Suvi-Tuulia Hämäläinen, Kaisa Turunen, Kari J Mattila, Elise Kosunen and Markku SumanenSuvi-Tuulia Hämäläinen, Kaisa Turunen, Kari J Mattila, Elise Kosunen and Markku Sumanen
Objective: In a previous questionnaire study, more breast cancers were reported by women with intrahepatic cholestasis of pregnancy (ICP) than by the controls. The aim of this study was to establish whether ICP is associated with cancer in the Finnish Cancer Registry data, the study population being the same cohort as in the questionnaire study.
Methods: The study population comprised 571 women with ICP in at least one pregnancy and 1,333 controls from Tampere University Hospital in Finland during 1969–1988. The cancer data were obtained from the Finnish Cancer Registry. The cancers were classified by ICD-O-3 and diagnosed during the period 1953−2013.
Results: In the ICP group, the odds ratio of cancers (OR 1.26, 95% CI 0.96–1.64), and breast cancer in particular (OR 1.36, 95% CI 0.91–2.03),.. View More»
DOI:
10.4172/2327-4972.1000216