Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Sarman Singh
All India Institute of Medical Sciences,
Ansari Nagar, New Delhi-110 029
India
Review Article
Glycogenomics of Mycobacterium tuberculosis
Author(s): Anil Kumar Gupta, Amit Singh and Sarman SinghAnil Kumar Gupta, Amit Singh and Sarman Singh
Glycogen is an important energy store of almost all living organisms. It is an alpha linked polymer comprised of thousands of glucose units. In bacteria it is usually synthesized when carbon ions are in excess in the growth medium and its synthesis helps for the survival of the bacteria under such nutritional conditions. Mycobacterium tuberculosis (M. tuberculosis), accumulates glycogen during the adverse condition such as reactive oxygen and nitrogen intermediates, low pH, nutrients and other vital element starvation for their survival in the host. Glycogen also plays a very important role in the pathogenesis of M. tuberculosis. The biosynthesis of glycogens is mediated by glycosyltransferases enzyme which can be divided into two families; glycogen transferase (GT) 3 and glycosyltransferases GT 5. Regulation of glycogen metabolism in bacteria involves a complex mech.. View More»
DOI:
10.4172/2161-1068.1000175