Advances in dairy Research
Open Access
ISSN: 2329-888X
ISSN: 2329-888X
Philip D Rye
Norway
Research Article
Alginate Oligomers Inhibit Growth of Bacteria Causing Bovine Mastitis and Potentiate the Activity of Antibiotics Commonly Used For Treatment of the Disease
Author(s): Anne Tøndervik, Geir Klinkenberg, Randi Aune, Philip D Rye and Håvard SlettaAnne Tøndervik, Geir Klinkenberg, Randi Aune, Philip D Rye and Håvard Sletta
Alginate oligomers have been shown to disrupt microbial biofilms and reduce minimum inhibitory concentrations (MIC) for many clinically relevant antibiotics to a range of human pathogens. The antibiofilm and potentiating effects of alginate oligomers has previously been focussed on bacterial and fungal strains that play significant roles in chronic human infections. This study on the effects of an alginate oligomer (OligoG CF-5/20) on bacteria that cause bovine mastitis is the first report that investigates a significant disease in animal health. The effect of OligoG CF-5/20 on the inhibitory concentrations of ampicillin, erythromycin, cephalothin and lincomycin to a test panel of nine bacterial strains associated with bovine mastitis were investigated. Two different media were used for cultivation, the standard Mueller-Hinton normally used for bacterial MIC determination, and a skimmed .. View More»
DOI:
10.4172/2329-888X.1000186