Advances in dairy Research
Open Access
ISSN: 2329-888X
ISSN: 2329-888X
Mohd Manap
Malaysia
Research Article
Nutrigenomic Effects of Fermented Milk Containing Bifidobacterium longum Bb536 on Hepatic Cholesterologenic Genes in Hypercholesterolemic Rats
Author(s): Sadeq Hasan Al-Sheraji, Amin Ismail, Azrina Azlan and Mohd ManapSadeq Hasan Al-Sheraji, Amin Ismail, Azrina Azlan and Mohd Manap
The aim of this study was to investigate the effects of fermented milk contains bifidobacteria on plasma lipid levels and selected genes in hypercholesterolemic rats. Effects of Bifidobacterium longum BB536 with prebiotics on body weight of rats, level of bile acids and selected genes were studied. Sprague-Dawley rats were randomly divided into groups. Negative control group received standard diet, positive control group received high-cholesterol diet, and intervention groups received high-cholesterol diet added with fermented milk contains Bifidobacterium longum BB536 in presences of prebiotics. After 8 weeks, body weight, level of bile acids were measured and low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase were investigated in rats’ liver using quantitative real-time polymerase chain reaction. Fermented milk conta.. View More»
DOI:
10.35248/2329-888X.19.7.220