Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Max R O’Donnell
Tanzania
Research Article
Discordance between Tuberculin Skin Test and Interferon Gamma Release Assay
is Associated with Previous Latent Tuberculosis Infection Treatment
Author(s): Divya Reddy, Max R O’Donnell, Allan M Welter-Frost, Alison Coe and C Robert HorsburghDivya Reddy, Max R O’Donnell, Allan M Welter-Frost, Alison Coe and C Robert Horsburgh
Background: The performance of Interferon gamma release assays (IGRA) in drug users and the impact of previous latent tuberculosis infection (LTBI) treatment on discordance of IGRA and tuberculin skin test (TST) are unclear.
Objective: To determine the prevalence and incidence of LTBI using TST and Quantiferon Gold In-Tube test (QFT-G-IT) in a cohort of persons with hepatitis C virus (HCV) and drug use history. Design: Eligible participants had baseline TST and QFT-G-IT assay and were retested with QFT-G-IT after 12 months to assess prevalence and incidence of LTBI.
Results: Of 193 HCV-infected persons enrolled, 162 (84%) were HIV infected; 132 (81%) were on anti-retroviral therapy and 131 (81%) had a CD4 count >200. 190 (98%) had a history of drug use; only 19 (10%) were active intravenous drug users.. View More»
DOI:
10.4172/2161-1068.1000227