Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Mahshid Salehi
West Indies
Research Article
Genetic Patterns of rpsL and rrs Genes in Clinical Isolates of Mycobacterium
tuberculosis, Isfahan‚ Iran
Author(s): Bahram Nasr Esfahani, Hossein Mirhendi, Fatemeh Riyahi Zaniani, Mahshid Salehi and Sediqeh KarimiBahram Nasr Esfahani, Hossein Mirhendi, Fatemeh Riyahi Zaniani, Mahshid Salehi and Sediqeh Karimi
Drug-resistant tuberculosis is considered a major universal problem. Based on knowledge on certain mutations occurring in Mycobacterium tuberculosis genome, drug resistance could be detected timely. The goal of this study was to determine the prevalence of the most common mutations likely to result from resistance to streptomycin in M. tuberculosis isolates, as well as genetic patterns of rpsL and rrs genes, in the province of Isfahan, Iran.
Clinical specimens were collected from individuals suspected of tuberculosis who referred to the Tuberculosis Center of Isfahan among whom 205 isolates were diagnosed with M. tuberculosis by conventional methods. The minimum inhibitory concentration of streptomycin in these isolates was determined with proportion method using Lowenstein- Jensen medium from which 10 isolates were recognized with streptomycin-resistant tuberculosis. The nu.. View More»
DOI:
10.4172/2161-1068.1000235