Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Lydia Mosi
Scotland
Review Article
Genotyping Tools for Mycobacterium ulcerans Drawbacks and Future Prospects
Author(s): Charles A Narh, Lydia Mosi, Charles Quaye, Samuel CK Tay, Bassirou Bonfoh and Dziedzom K de SouzaCharles A Narh, Lydia Mosi, Charles Quaye, Samuel CK Tay, Bassirou Bonfoh and Dziedzom K de Souza
Mycobacterium ulcerans infection (Buruli ulcer) is a neglected but treatable skin disease endemic in over 30 countries. M. ulcerans is environmental mycobacteria with an elusive mode of transmission to humans. Ecological and Molecular epidemiological studies to identify reservoirs and transmission vectors are important for source tracking infections especially during outbreaks and elucidating transmission routes. Research efforts have therefore focused on genotyping strains of the mycobacteria from clinical and environmental samples. This review discusses genotyping tools for differentiating M. ulcerans strains from other environmental and Mycolactone Producing Mycobacteria (MPMs). We highlight tools that have been adapted from related fields and propose ways these could be enhanced to resolve intra-species variation for epidemiological, transmission, evolutionary studies, and detecti.. View More»
DOI:
10.4172/2161-1068.1000149