Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Lesibana Anthony Malinga
Medical Research Council, TB Platform, Pretoria,
South Africa
Review Article
Efflux Pump Mediated Second-Line Tuberculosis Drug Resistance
Author(s): Lesibana Anthony Malinga, Anton Stoltz and Martie van der WaltLesibana Anthony Malinga, Anton Stoltz and Martie van der Walt
The burden and spread of drug-resistant tuberculosis disease is a major public health problem worldwide. The causative agent, Mycobacterium tuberculosis uses several mechanisms to counteract therapy through drugresistance. A major and most common mechanism of drug-resistance is mediated through target mutations. Efflux pumps are emerging as potential agents of drug-resistance and treatment failure. In this review we explore the origin and principles of efflux pump-mediated resistance and determine their impact on second-line drugs used against extensively drug resistant tuberculosis. Inhibition of efflux pumps as a therapeutic intervention is also discussed... View More»
DOI:
10.4172/2161-1068.1000222