Advances in dairy Research
Open Access
ISSN: 2329-888X
+44 1300 500008
ISSN: 2329-888X
+44 1300 500008
Jorg Lehmann
Fraunhofer Institute for Cell Therapy and Immunology,
Perlickstr, 1, 04103 Leipzig
Germany
Research Article
Discovery and Validation of Immunological Biomarkers in Milk for Health Monitoring of Dairy Cows - Results from a Multiomics Approach
Author(s): Zoldan K, Schneider J, Moellmer T, Fueldner C, Knauer J, Fuerll M, Starke A, Specht M, Reiche K, Hackermueller J, Kalkhof S, von Bergen M, Bergfeld U, Fischer R, Pache S and Jorg LehmannZoldan K, Schneider J, Moellmer T, Fueldner C, Knauer J, Fuerll M, Starke A, Specht M, Reiche K, Hackermueller J, Kalkhof S, von Bergen M, Bergfeld U, Fischer R, Pache S and Jorg Lehmann
At onset of milk production and in early lactation highly producing dairy cows are most susceptible for inflammatory diseases due to functional suppression of immune cells. Intensive supervision of the animals is essential and implementation of new technologies to on-farm routines will be the next step to provide automation and improvement of herd health monitoring programs. Objective of our study was to identify and validate immunological biomarkers in milk that indicate extra-mammary inflammatory diseases to characterize the general health status of highly-producing dairy cows.
In total 89 healthy and 75 diseased animals (German Holstein cows) were included. Diseases were distinguished by either systemic (extra-mammary) occurrence or those affecting the mammary gland (mastitis) and further classified by their severity. For protein biomarker discovery we used a top-down app.. View More»
DOI:
10.4172/2329-888X.1000182