Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Diego Ferrer
Spain
Research Article
Association of Human Leukocyte Antigens Class I and II Variants with Susceptibility to Pulmonary Tuberculosis in a Caucasian Population from
Northern Spain
Author(s): Gonzalo Ocejo-Vinyals J, Fernando Ausín, Elena Puente de Mateo, José Luis Arroyo, Ramón Agüero, Diego Ferrer, Carmen Fariñas M and Francisco Leyva-CobiánGonzalo Ocejo-Vinyals J, Fernando Ausín, Elena Puente de Mateo, José Luis Arroyo, Ramón Agüero, Diego Ferrer, Carmen Fariñas M and Francisco Leyva-Cobián
Background: Susceptibility to TB seems to be multifactorial, and the development of active disease is probably the result of complex interactions between the host and pathogen, influenced by environmental and genetic factors. The Human Leukocyte Antigen system or HLA seems to be one of these factors. Differences in the distribution of HLA alleles and haplotypes have been found worldwide with conflicting results among different populations and few data concerning Caucasian populations have been reported.
Methods: Distribution of HLA class I and class II alleles was evaluated in 160 Spanish patients with pulmonary tuberculosis, all of them HIV negative, 109 latently infected individuals, and in 262 healthy individuals. All the subjects included in the study belonged to the same geographical area (Cantabria, northern Spain).
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DOI:
10.4172/2161-1068.1000132