Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Beenu Joshi
National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR),
Taj Ganj, Agra
India
Research Article
Differential Cytokine Response and IgG Subclasses in Pulmonary TB Patients,
Household Contacts and BCG Vaccinated PPD-ve Healthy Controls
Author(s): Rakesh Patel, Rajni Upadhyay, Bharat Bajaj, V.S.Yadav, Nalini Srivastava, D.S.Chauhan, Santosh K Kar and Beenu JoshiRakesh Patel, Rajni Upadhyay, Bharat Bajaj, V.S.Yadav, Nalini Srivastava, D.S.Chauhan, Santosh K Kar and Beenu Joshi
Immune response to Mycobacterium tuberculosis is complex and some cytokines are believed to be involved in protective response in humans. In the present study the levels of IFNγ, IL-17, IL-10 and IL-2 stimulated by PPD and ESAT-6 in the PBMCs of active untreated pulmonary TB patients (PTB), their PPD+ve household contacts (HHC) and PPD-ve healthy controls (H) has been estimated at the start and 2 months and 6 months after the start of treatment. IgG subclass antibodies to ESAT-6 and Ag85 complex circulating in the serum of the study subjects on the same days were also measured. Significantly elevated levels of cytokines were secreted by the unstimulated PBMC of patients and HHC in comparison to healthy individuals. PPD significantly increased the secretion of all the measured cytokines by the PBMC of healthy individuals and patients. Higher levels of IL-2 and lower levels of IL-.. View More»
DOI:
10.4172/2161-1068.1000198