Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
Asesh Banerjee
All Asia Medical Institute,
8B Garcha First Lane, Kolkata- 700019
India
Research Article
Molecular Genetic Determination of MDR–TB Isolates from West Bengal, India
Author(s): Supabitra Hazra, Santanu Karmakar, Supratik Ghosh, Sandip Roy, Brojo Kishore Saha, Santanu Halder and Asesh BanerjeeSupabitra Hazra, Santanu Karmakar, Supratik Ghosh, Sandip Roy, Brojo Kishore Saha, Santanu Halder and Asesh Banerjee
Tuberculosis (TB) is one of the leading causes of death from an infectious disease worldwide. India remains to be the country carrying highest burden of the disease. One of the potent problems of present days, in this field, is the emergence of Multi-Drug-Resistant Tuberculosis (MDR-TB). MDR is defined as resistance to isoniazid (INH) and rifampin (RIF). The spread of MDR-TB is one of the biggest challenges to global public health system. Thus, detection of MDR-TB strains is critically important for containment of global TB epidemics. In this study, we are determining the MDR incidence rate in the West Bengal state of India, which is one of the most TB prone areas of the world. The RIF-resistant mutations of Mycobacterium tuberculosis (MTB) were shown to map in the rpoB locus and INH-resistant mutations of MTB were shown to map in inhA and katG loci. Therefore, in the present.. View More»
DOI:
10.4172/2161-1068.1000252