Journal of Genetic Syndromes & Gene Therapy
Open Access
ISSN: ISSN: 2157-7412
ISSN: ISSN: 2157-7412
Yasukatsu Izumi
Japan
Editorial
Therapeutical Potential of Microvesicles in Cardiovascular Diseases
Author(s): Yasukatsu IzumiYasukatsu Izumi
MicroRNAs (miRNAs) are small, highly conserved, non-coding RNA molecules that regulate hundreds of gene expression and thereby, affect global changes in the physiology of cells. Extracellular miRNAs are packaged with proteins or wrapped in microvesicles including microparticles, exosomes, and apoptotic bodies. These vesicles are potential candidates for therapeutical targets. Recent studies have indicated that microvesicles have the roles of deleterious information in blood vessel wall under pathological situations such as hypertension, myocardial infarction and metabolic syndrome, whose diseases are results of the endothelial dysfunction. However, the role of endothelial cells-derived microvesicles is unknown. Uncovering the difference and potential role of these microvesicles in endothelial cells is emerging.. View More»
DOI:
10.4172/2157-7412.1000e107