Journal of Genetic Syndromes & Gene Therapy
Open Access
ISSN: ISSN: 2157-7412
ISSN: ISSN: 2157-7412
Yan Li
Laboratory of Immunology Institute of Basic Medical Sciences, P.O. Box 130 (3)Taiping Road #27 Beijing 100850,
China
Research Article
Identification of the Key Functional Domain of BAFF for Binding TACI by Computer-Guided Molecular Modeling Method
Author(s): Ru Wang, Zhou Lin, Hui Peng, Huawei Wei, Xinying Li, Jian Sun, Jianmin Fang, Ning Li, Xiangbin Meng, Beifen Shen, Jiannan Feng and Yan Li
Ru Wang, Zhou Lin, Hui Peng, Huawei Wei, Xinying Li, Jian Sun, Jianmin Fang, Ning Li, Xiangbin Meng, Beifen Shen, Jiannan Feng and Yan Li
As an important member of the Tumor Necrosis Factor (TNF) super family, B cell activating factor (BAFF: also known as BLyS, TALL-1, THANK and zTNF4 or TNFSF13b) induces B cell proliferation and differentiation both in vivo and in vitro. A series of experimental results showed that the soluble form of a BAFF receptor, trans-membrane activator and CAML-interactor (TACI), could alleviate the autoimmune symptoms of NZBWF1 and MRL-lpr/lpr mice. Furthermore, the fusion protein TACI-Fc, as a novel BAFF antagonist, was used to the treatment of relapsing multiple sclerosis. However, it is not clear how BAFF interact with its receptor TACI. In this study, using the crystal structures of BAFF and its receptor TACI, the binding mode and the key domains of BAFF interaction with TACI were analyzed based on the computer-guided molecular modeling method. According to the theoretical predictions, a serie.. View More»
DOI:
10.4172/2157-7412.1000114