Journal of Genetic Syndromes & Gene Therapy
Open Access
ISSN: ISSN: 2157-7412
+44 1223 790975
ISSN: ISSN: 2157-7412
+44 1223 790975
Ueki H
Japan
Review Article
Koebner Phenomenon in Rheumatoid Arthritis
Author(s): Yamamoto T and Ueki HYamamoto T and Ueki H
Koebner phenomenon indicates the newly appearance of isomorphic lesions at the sites of mechanically stimulated or injured skin. This phenomenon can be seen in various inflammatory, auto-immune, viral, fibrotic, and even tumoral disorders. Also, rheumatic diseases such as lupus erythematosus, dermatomyositis, and rheumatoid arthritis (RA) often present with cutaneous manifestations with isomorphic response of Koebner. RA presents with various skin conditions as extra-articular manifestations. Rheumatoid nodule is the representative specific skin lesion which frequently occurs on the hand, elbow, sole, sacrum, occipital area, and so on. These sites are susceptible to both outer and inner mechanical stress. Rheumatoid nodules involve not only skin but internal tissues such as spine, lung, heart valves, and gastrointestinal tract, which are also susceptible to mechanical stress. This iso.. View More»
DOI:
10.4172/2157-7412.1000173