Translational Medicine

Translational Medicine
Open Access

ISSN: 2161-1025

+44 1223 790975

Sourav Ghosh

Sourav Ghosh


  • Research Article
    Hepatoprotective Efficacy of Gold Nanoparticle Synthesized by Green Method Using Trigonella Foenum-Graecum Seed Extract
    Author(s): Sourav Ghosh and Antony GomesSourav Ghosh and Antony Gomes

    Earlier study showed the effective hematopoietic potential of gold nanoparticle (FG-GNP) synthesized using fenugreek seed aqueous extract. The present work was an effort to establish the hepatoprotective activity of FG-GNP in animal model. Swiss albino male mice (n=4) were grouped into: Gr.1- Sham Control, Gr.2- CCl4 treated (1.5ml/kg), Gr.3- Standard Drug (Silymarin) treated (100mg/kg/p.o.), Gr.4- Fenugreek treated (100mg/kg/p.o.), Gr.5- FG-GNP treated (0.5mg/kg/p.o.). Biochemical parameters (AST, ALT, γGT, ACP, ALP, total bilirubin), pro-inflammatory parameters (IL 1β, IL 17, TNF α), anti-inflammatory parameters (IL 10, Cathepsin K), antioxidant parameters (GSH, SOD, Catalase) and prooxidant parameter (LPO) were assayed. Histology of liver tissue was done. AST and ALT release from liver tissue was done by in vitro liver slice model. Statistical analysis was don.. View More»

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