Journal of Genetic Syndromes & Gene Therapy
Open Access
ISSN: ISSN: 2157-7412
+44 1223 790975
ISSN: ISSN: 2157-7412
+44 1223 790975
Sarita Agarwal
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh,
India
Research Article
Folate Metabolism and Genetic Variant in Down Syndrome: A Meta-Analysis
Author(s): Ambreen Asim, Sarita Agarwal, Sakil Subhash Kulkarni and Inusha PanigrahiAmbreen Asim, Sarita Agarwal, Sakil Subhash Kulkarni and Inusha Panigrahi
Objectives: Studies investigating the association between gene polymorphisms involved in homocysteine/folate metabolism and Down syndrome (DS) have reported contradictory or inconclusive results. A meta- analysis of 25 studies on association between MTHFR and MTRR polymorphism and DS including 1, 934/2,081/ cases/controls for MTHFR C677T polymorphism, 1,404/1,632/ cases/control for MTHFR A1298C polymorphism and 859 /1,132/cases/ control for MTRR A66G polymorphism was carried out. Study design: Studies were identified by searching the PubMed database for relevant articles published. Case – control studies were chosen, and odds ratio (OR) with confidence interval (CI) were used to assess the strength of association. Results: The overall results suggested that the variant genotypes MTHFR C677T were associated with DS risk (homozygote, TT vs. CC: OR=2.991; 95% CI: 1.321-3.558; P=0.0.. View More»
DOI:
10.4172/2157-7412.1000270