Translational Medicine

Translational Medicine
Open Access

ISSN: 2161-1025

Sandeep Satapathy

Sandeep Satapathy
Indian Institute of Science Education and Research,

  • Review Article
    Human Papilloma Virus (HPV) Vaccines: Scope and Implications
    Author(s): Roshan Kumar Singh, Sandeep Satapathy and Abhilasha SinghRoshan Kumar Singh, Sandeep Satapathy and Abhilasha Singh

    High risk human papilloma virus has often been associated with cancer onset and progression by the virtue of the viral oncogenes. Genital cancers and Oropharyngeal cancers are the two leading carcinomas often induced by HPV infection. These viral encoded oncogenes (e.g. E6/E7/E8) are known for their ability to integrate, recombine and interfere with the host cellular genes. Although significant work has been undertaken and several more in progress in understanding the disease biology, yet attaining an effective and long term protection from HPV associated cancers remains unachieved. Lack of any drug based therapy or post-infection treatment strategy along with limited commercially available vaccines (e.g. Gardasil and Cervarix) have crippled our efforts to curb the disease manifestation cancers, remains. Therefore, in this review we aim to address the contemporary rational of HPV vacc.. Read More»
    DOI: 10.4172/2161-1025.1000180

    Abstract PDF

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