Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Rashmi BS
India
Research Article
Development of Celiac Disease; Pathogenesis and Strategies to Control: A
Molecular Approach
Author(s): Devaraja Gayathri and Rashmi BSDevaraja Gayathri and Rashmi BS
Celiac disease (CD) is an intestinal chronic disorder with multifactorial etiology resulting in small intestinal mucosal injuries and malabsorption. Trigger from gluten and related cereal proteins, HLA-DQ2/DQ8 molecules and autoantibodies to tissue transglutaminase, are essential to precipitate the disease. Genetic, dietary and immunological factors explain geographically regional differences in CD. Specific anchoring sites in DQ2/DQ8 peptide binding motifs show affinity to tTG deamidated peptides of gluten and present to gluten restricted T cells to form celiac lesions. The present article reviews the causes, molecular details of CD development, strategies to control and significance of probiotics in reducing the gluten burden in CD... View More»
DOI:
10.4172/2155-9600.1000310