Translational Medicine
Open Access

Praveen Rishi

Publications

• Research Article
  Nisin Augments Doxorubicin Permeabilization and Ameliorates Signaling Cascade during Skin Carcinogenesis
  Author(s): Simran Preet*, Satish K Pandey, Navjot Saini, Ashwani Koul and Praveen RishiSimran Preet*, Satish K Pandey, Navjot Saini, Ashwani Koul and Praveen Rishi
  
  Background: Multidrug resistance exhibited by cancerous cells has proved to be a big hurdle in the development of an effective anti-cancer therapy. We previously demonstrated nisin-doxorubicin adjunct therapy to exhibit strong additive anti-cancer effect against DMBA –induced murine skin carcinogenesis but the mechanism remained unexplored. Methods: The in vivo tumoricidal activity of the combination was validated in terms of animal bioassay observations while ex vivo anti-cancer effect was monitored by employing HaCat cell lines. Results: The combination was found to be additive in vivo as evidenced by larger decreases in mean tumor burden and tumor volumes. The IC50 values of nisin and DOX alone were evaluated to be 16 μ.. View More»
  DOI: 10.4172/2161-1025.1000161

  Abstract PDF

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