Journal of Down Syndrome & Chromosome Abnormalities

Journal of Down Syndrome & Chromosome Abnormalities
Open Access

ISSN: 2472-1115

+44 1223 790975

Papiya Ghosh

Papiya Ghosh


  • Review Article
    Genetic Etiology of Chromosome 21 Nondisjunction and Down syndrome Birth: Aberrant Recombination and Beyond
    Author(s): Sujay Ghosh and Papiya GhoshSujay Ghosh and Papiya Ghosh

    Aberrant recombination pattern is known as risk factor for Chromosome 21 nondisjunction in oocyte and subsequent Down syndrome child birth. A considerable fraction of recombining chromosomes that missegregates exhibits erroneous pattern of single chiasma placement along the length of chromosome 21, either very close to centromere or very close to telomere. This pattern differs significantly from the chromosomes that segregate correctly. Researchers have also found an interaction of maternal age with aberrant pattern of single chiasma positioning on the chromosome and the interaction differs according to stage of meiotic origin of error i.e., meiosis I or meiosis II. Moreover, study on nondisjoined chromosome 21 that carries two simultaneous chiasmata revealed such chromosomes have tendency to missegregate in meiosis II. In meiosis I error double chiasmate chromosome exhibits shifting .. View More»
    DOI: 10.4172/2472-1115.1000102

    Abstract PDF

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