Journal of Genetic Syndromes & Gene Therapy
Open Access
ISSN: ISSN: 2157-7412
+44 1223 790975
ISSN: ISSN: 2157-7412
+44 1223 790975
Ming Li
Japan
Research Article
Fetal Liver-Derived Stem Cells Ameliorate Adipocyte Functions in Obese Mice
Author(s): Ming Li, Kequan Guo, Yunze Cui, Yasushi Adachi and Susumu IkeharaMing Li, Kequan Guo, Yunze Cui, Yasushi Adachi and Susumu Ikehara
Fetal liver (FL) contains hepatic stem cells, hematopietic stem cells, and mesenchymal stem cells, as well as pluripotent stem cells and very small embryonic-like stem cells. FL has thus been available as a source of stem cells for regenerative medicine. Our previous report suggested that combining FL cell transplantation with the transplantation of fetal thymus prevented tumor growth in tumor-bearing mice. Moreover, in animal models, intra bone marrow-bone marrow transplantation (IBM-BMT) has proven to be the best approach for allogenic BMT. We here propose that transplanting FL cells by IBM-BMT can improve adipocyte functions in obese mice. FL cells were collected from FLs of C57BL/6 mice at 16 days post coitum, and then transplanted by IBM-BMT to db/db mice, an animal model of type 2 diabetes with obesity. Our results showed that the body weight was significantly lower in the treated .. View More»
DOI:
10.4172/2157-7412.1000263