Journal of Genetic Syndromes & Gene Therapy
Open Access
ISSN: ISSN: 2157-7412
+44 1223 790975
ISSN: ISSN: 2157-7412
+44 1223 790975
Miller RH
Department of Neurosciences, Center for Translational Neuroscience,
School of Medicine, Cleveland OH 44106
Tanzania
Review Article
Adult NG2-Expressing Cells in Multiple Organs: A Novel Progenitor in Regenerative Medicine
Author(s): Zhang H, Zhang X, Bie P, Miller RH and Bai LZhang H, Zhang X, Bie P, Miller RH and Bai L
Stem/progenitor cells have emerged as a promising tool for studying the mechanisms of cell development, tissue regeneration, and cell therapy for various disorders. Stem/progenitor cells are found not only in the embryo but also in most adult tissues for endogenous repair. They are capable of self renewal and differentiation into various cell types from their germ line, thus, are ideal candidates for cell-based therapy. Expression of neuron-glial antigen 2 (NG2) proteoglycan is found on several types of cell surface, majorly distributing on undifferentiated precursor cells in the Central Nerve System (CNS), named Oligodendrocyte Progenitor Cells (OPCs). NG2 proteoglycan has a widespread range of physiological roles and the cells that express chondroitin sulphate proteoglycan NG2/CSPG4 (NG2+cells) react to all forms of pathological insults. This cell population is abundant in the devel.. View More»
DOI:
10.4172/2157-7412.S3-008