Journal of Genetic Syndromes & Gene Therapy
Open Access

Menga G

Publications

• Research Article
  Significant Increase of IL-8 Sputum Levels in Treatment Resistant Severe Asthma Compared with Difficult to Treat Severe Asthma Patients
  Author(s): Ernst G, Auteri S, Caro F, Colodenco D, Fernandez M, Menga G, Morero JL, Neffen H and Schiavi E Ernst G, Auteri S, Caro F, Colodenco D, Fernandez M, Menga G, Morero JL, Neffen H and Schiavi E
  
  The spectrum of severe asthma includes different groupings and phenotypes. World Health Organization proposes to differentiate two categories: difficult-to-treat-severe asthma (DTTSA) and treatment-resistant-severe asthma (TRSA). DTTSA includes controllable severe asthma and TRSA includes patient?s not achieving adequate levels of control and persisting indicators of severity despite receiving and using maximum levels of inhaled medications. We hypothesized that granulocyte counts from sputum samples could differentiate pathogenic differences between both groups. We analyzed the number of sputum neutrophils and eosinophils in both categories of severe asthma patients admitted for an asthma exacerbation in a respiratory-based hospital. We also compared our results with mild to moderate asthma patients (MMA) and healthy controls (HC). We measured cytokines levels relevant to neutrophil rec.. View More»
  DOI: 10.4172/2157-7412.1000218

  Abstract PDF

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