ISSN: 2155-9600
Loredana Quadro
Department of Food Science and Rutgers Center for Lipid Research; Rutgers University, New Brunswick, NJ 08901, USA
Our research focuses on understanding the metabolism of fat-soluble vitamins and its influence on human health, at different stages of the life cycle. By taking advantage of genetically modified mouse models, our laboratory is specifically interested in the metabolism of vitamin A and its main dietary carotenoid precursor b-carotene.
Vitamin A is essential to maintain reproduction, development, vision, and immune function. Furthermore, retinoids (vitamin A and its derivatives) are known to modulate cell growth, differentiation and apoptosis. Alterations of vitamin A metabolism have been associated with human diseases as diverse as retinal dystrophies, cancer, type 2 diabetes and the Matthew Wood Syndrome.
We primarily focus on the study of the molecular, biochemical and physiological mechanisms that regulate the metabolism of vitamin A and b-carotene during mammalian embryogenesis, in both maternal and developing tissues.