Translational Medicine
Open Access
ISSN: 2161-1025
+44 1223 790975
ISSN: 2161-1025
+44 1223 790975
Liu Yang
Shanghai Ninth People’s Hospital, School of Medicine,
China
Research Article
Associations between Markers of Colorectal Cancer Stem Cells, Mutations, Mirna, and Clinical Characteristics of Ulcerative Colitis
Author(s): Liu Yang, Edi Levi, JianHua Du, HengHua Zhou, Rebecca Miller and Adhip PN MajumdarLiu Yang, Edi Levi, JianHua Du, HengHua Zhou, Rebecca Miller and Adhip PN Majumdar
Background: Several factors have been implicated in the pathogenesis of colorectal cancer (CRC) associated with ulcerative colitis (UC). We investigated markers of cancer cell pluripotency, including CD44 and CD166, microRNA-21 (miR-21) and microRNA-215 (miR-215), and APC, K-ras and DCC mutations in biopsy specimens from patients with UC to evaluate any correlations with clinical risk factors.
Methods: We observed 18 patients with UC and collected two biopsy specimens from each patient at diagnosis and at a follow-up endpoint. We examined the expression of CD44, CD166, miR-21 and miR-215 as well as APCKras and DCC mutations. We compared these markers from the two points in time and assessed their associations with clinical characteristics, including colitis duration, histological alterations, and patient age at UC onset.
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DOI:
10.4172/2161-1025.1000168