Translational Medicine

Translational Medicine
Open Access

ISSN: 2161-1025

+44 1223 790975

Liang Cheng

Liang Cheng


  • Review Article
    Personalized Medicine in Oncology and Companion Diagnostics:Development and Challenges
    Author(s): Hanh La, Liang Cheng and Chong-Xian PanHanh La, Liang Cheng and Chong-Xian Pan

    Caveolae are flask-like invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the marker protein caveolin and the coat protein cavin. In cardiomyocytes, multiple signaling molecules are concentrated and organized within the caveolae to mediate signaling transduction. Recent studies suggest that caveolae and caveolaeassociated signaling molecules play an important role in protecting the myocardium against ischemia-reperfusion injury. For example, cardiac-specific overexpression of caveolin-3 has been shown to lead to protection that mimics ischemic preconditioning, while the knockout of caveolin-3 abolished ischemic preconditioning. In this review, we discuss the molecular mechanisms and signaling pathways that are involved in caveolae-mediated cardioprotection, and examine the potential for caveolae as a therapeutic target for pharmaceutical intervention to trea.. View More»
    DOI: 10.4172/2161-1025.1000113

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