Translational Medicine
Open Access
ISSN: 2161-1025
+44 1223 790975
ISSN: 2161-1025
+44 1223 790975
Junhui Sun
Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health,
10 Center Drive, Bldg10/ Rm8N206, Bethesda, MD 20892
Tanzania
Review Article
Cardioprotective Role of Caveolae in Ischemia-Reperfusion Injury
Author(s): Junhui Sun, Tiffany Nguyen, Mark J Kohr, Sara Menazza and Elizabeth MurphyJunhui Sun, Tiffany Nguyen, Mark J Kohr, Sara Menazza and Elizabeth Murphy
Caveolae are flask-like invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the marker protein caveolin and the coat protein cavin. In cardiomyocytes, multiple signaling molecules are concentrated and organized within the caveolae to mediate signaling transduction. Recent studies suggest that caveolae and caveolaeassociated signaling molecules play an important role in protecting the myocardium against ischemia-reperfusion injury. For example, cardiac-specific overexpression of caveolin-3 has been shown to lead to protection that mimics ischemic preconditioning, while the knockout of caveolin-3 abolished ischemic preconditioning. In this review, we discuss the molecular mechanisms and signaling pathways that are involved in caveolae-mediated cardioprotection, and examine the potential for caveolae as a therapeutic target for pharmaceutical intervention to trea.. View More»
DOI:
10.4172/2161-1025.1000114