Transcriptomics: Open Access

Transcriptomics: Open Access
Open Access

ISSN: 2329-8936


Jing Hao

Jing Hao


  • Editorial
    Maintain Genomic Stability: Multitask Of DNA Replication Proteins
    Author(s): Jing Hao and Wenge ZhuJing Hao and Wenge Zhu

    Maintenance of genomic stability is critical for living organisms because it is crucial for cell survival and development, and it prevents the development of deleterious mutations. Overriding this control will cause genomic instability, a hallmark of cancer. The genome is highly vulnerable to damage, especially during DNA replication because chromosome is decondensed and the replication forks are extremely sensitive to DNA damage agents. The eukaryotic replisome, which consists of a large number of replication fork-associated proteins, is essential for the elongation of replication forks during DNA replication. This complex contains DNA polymerases, MCM helicase, single stranded DNA (ssDNA) binding protein RPA, sliding clamp PCNA, Tipin, Timeless, Claspin, And-1, etc. In cells with DNA damage such as replication stress, replication forks are s.. Read More»
    DOI: 10.4172/2329-8936.1000e108

    Abstract PDF

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