Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Jie Chen
Tanzania
Special Issue Article
IGF-1 Mediates Exercise-Induced Phospholipid Alteration in the Murine Skin Tissues
Author(s): Yu Jiang, Haitian Ma, Xiaoyu Su, Jie Chen, Jianteng Xu, Joseph Standard, Dingbo Lin and Weiqun WangYu Jiang, Haitian Ma, Xiaoyu Su, Jie Chen, Jianteng Xu, Joseph Standard, Dingbo Lin and Weiqun Wang
We previously demonstrated that exercise with an iso-caloric diet significantly reduced body weight and skin carcinogenesis in correspondence with lower plasma IGF-1 levels and IGF-1-dependent phospholipid signaling. This study was thus designed to test the hypothesis that IGF-1 reduction plays a causal role in exercise-induced phospholipid changes. SENCAR mice were randomly assigned to one of the following three groups for 12 weeks: ad libitum-fed sedentary control, exercise but pair-fed the amount of the control (PE), and PE with IGF-1 injection (PE+IGF-1). Treadmill exercise was conducted at 13.4 m/min for 90 min/d, 5 d/week. In the last two weeks IGF1 was i.p. injected (10 μg/g B.W.) twice per week. Both body weight and plasma IGF-1 levels were significantly reduced in PE mice when compared with the control. IGF-1 injection did not affect body weight, or the plasma levels of IG.. View More»
DOI:
10.4172/2155-9600.S2-003