Journal of Proteomics & Bioinformatics
Open Access

Hicham Bouabe

Publications

• Research Article
  Polypeptide Rearrangement Hypothesis and It's Implication in Genetic Diversity
  Author(s): Hicham BouabeHicham Bouabe
  
  Protein splicing is a post-translational process, in which a nested intervening sequence (intein) is spliced out of the interior of a polypeptide precursor, and the flanking protein fragments (exteins) are ligated to form a mature protein. This process was identified in yeast, bacteria and the plant jackbean, and recently for MHC class I antigen processing in vertebrates. Thus, it seems very likely that, besides antigens, functional proteins could be synthesized by post-translational splicing in vertebrates. Protein splicing indicates that proteins, after their translation, can evolve and change/exchange their sequences. The availability of natural mechanisms of protein splicing leads to the assumption that such and/or similar mechanisms might exist enabling in vivo polypeptide rearrangement in a large scale and in a diverse manner. Thus, I propose here a polypeptide .. View More»
  DOI: 10.4172/jpb.1000042

  Abstract PDF

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