Transcriptomics: Open Access
Open Access
ISSN: 2329-8936
+44 1223 790975
ISSN: 2329-8936
+44 1223 790975
Ganesh Chandra Jagetia
Tanhril, Aizawl-796 004, Mizoram
India
Research Article
Hesperidin, A Citrus Bioflavonoid Reduces the Oxidative Stress in the Skin of Mouse Exposed to Partial Body γ-Radiation
Author(s): Ganesh Chandra Jagetia and Mallikarjuna Rao KVNGanesh Chandra Jagetia and Mallikarjuna Rao KVN
Generation of reactive oxygen species (ROS) is one of the important and early events after exposure to ionizing radiations and this ROS production is responsible for the degenerative changes ensuing irradiation. An attempt has been made to modulate the radiation induced-ROS by hesperidin (hesperitin-7-rhamnoglucoside), a bioflavonoid in the wounded skin of irradiated mouse. The lower half of the animals was shaved and the animals were orally administered or not with 100 mg/kg body weight of hesperidin before exposure to 6 Gy of partial body gamma-radiation. The activities of glutathione peroxidase, superoxide dismutase and glutathione concentration as well as lipid peroxidation were estimated in the skin of mouse at 0, 1.5, 3, 6, 12, 24 and 48 h post-irradiation. Irradiation of mouse to 6 Gy caused a significant depletion in the activities of glutathione peroxidase, superoxide dismuta.. View More»
DOI:
10.4172/2329-8936.1000111