Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
+32 25889658
ISSN: 2155-9600
+32 25889658
Denis Medeiros
Tanzania
Research Article
Wolfberry Water Soluble Phytochemicals Down-Regulate ER Stress Biomarkers and Modulate Multiple Signaling Pathways Leading To Inhibition of Proliferation and Induction of Apoptosis in Jurkat Cells
Author(s): Yu Jiang, Yunong Zhang, Logan Wark, Edlin Ortiz, Soyoung Lim, Hui He, Weiqun Wang, Denis Medeiros and Dingbo LinYu Jiang, Yunong Zhang, Logan Wark, Edlin Ortiz, Soyoung Lim, Hui He, Weiqun Wang, Denis Medeiros and Dingbo Lin
Phytochemicals have received much recent attention in cancer prevention through simultaneous targeting multiple pathways in the disease progression. Here we determined that wolfberry phytochemicals was chemopreventive on the leukemic Jurkat cell. The water soluble wolfberry fractions (i.e., wolfberry phytochemicals) were enriched in carbohydrates (73.4 ± 4.5 % (w/w)), polyphenolics (1555 ± 112 mg quercetin equivalent / 100 g freeze dry powder, including 213 mg rutin/100 g freeze dry powder), and had enhanced antioxidant activity (7771 ±207 μM Trolox equivalent/ 100 g freeze dry powder). Wolfberry phytochemicals, but not purified wolfberry polysaccharide fractions, inhibited Jurkat cell proliferation, induced cycle arrest at the G2/M phase in a dose dependent manner starting at 1 mg/ml for 48 h. Wolfberry phytochemicals eliminated cellular reactive oxygen specie.. View More»
DOI:
10.4172/2155-9600.S2-001