Journal of Nutrition & Food Sciences
Open Access

The development in diagnosis of sub clinic cobalamin deficiency

6^th International Conference and Exhibition on Nutrition

September 14-16, 2016 San Antonio, USA

Selda Demirtas

Ufuk University, Turkey

Posters & Accepted Abstracts: J Nutr Food Sci

Abstract :

The growing data indicates that subclinical cobalamin deficiency (SCCD) is being diagnosed more than ever. Because of its common occurrence than classical cobalamin deficiency, SCCD is an important condition for public health. One question with SCCD is whether it is only a state of mild metabolic abnormality without any clinical signs or symptoms or is associated with clinical signs and symptoms, albeit vague. The exact prevalence of SCCD which is more frequent in young and middle aged adults is largely unknown. Furthermore, the absence of ideal test marker for cobalamin deficiency is aggravating the situation. It is clear that these problems can be solved with the evaluation of reference values of cobalamin and related tests in each population. In our current reference range study, serum cobalamin, folate and holotranscobalamin (Holo-TC) values, plasma homocystein and methyl malonic acid (MMA) levels were assayed in over the 400 healthy volunteers. The results indicated that, all of the tests except for the plasma homocysteine and MMA were found lower than detected by the manufacturer. They were divided to subgroups with respect to ages. Cobalamin and Holo-TC values of youngest group differ from the oldest group. So, we suggest the use of own reference values for each population and Holo-TC should be used together with the serum cobalamin in diagnosing SCCD. In another study, we observed that the cognitive test scores elevated with the increase of Vitamin B12 in young and middle-aged. In conclusion, SCCD is a hidden health problem that could be manifested by itself with a cognitive failure in the young and middle aged population. The serum cobalamin around 190-250 pg/ml should be considered for the diagnosis of SCCD which manifested by the cognitive impairment and cognitive functions should be assayed to provide exact diagnose.

Biography :

Email: seldademirtas@yahoo.com