Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Mae Genevieve G Cheung, Michael G Cuevas, Lovely Fe L Cuison, Elijin P Dai, Katrina Marie S Duron, Azalea Damaris E Encarnacion, May T Magtoto and Gina C Castro
University of Santo Tomas, Philippines
Posters & Accepted Abstracts: J Nutr Food Sci
Previous in vitro study conducted on Blumea balsamifera leaf extract proved that it has a strong anti-obesity potential by inhibiting adipogenesis in 3T3-L1 adipocytes. This study aims to evaluate the effectiveness of Blumea balsamifera aqueous (BBAE) and ethanolic (BBEE) leaf extracts in managing obesity of diet-induced obese Sprague-Dawley rats. Induction of obesity was done by feeding the groups with a high fat diet (HFD) for 21 days with the exception of one group that received a standard diet (SD). Administration of the treatment was given for 24 days via oral gavage with the following doses: 300 mg/kg BBAE and BBEE, 600 mg/ kg BBAE and BBEE and 21.6 mg/kg Orlistat. The Lee��?s index and lipid profile of the groups were compared during the post induction and post treatment period. 600 mg/kg dose of BBAE and BBEE had greatly lowered the Lee��?s index among the other doses. 300 mg/ Kg dose BBEE, 600 mg/Kg BBAE and 300 mg/kg BBAE lowered the total cholesterol level, LDL level and VLDL and total triglyceride level respectively. The extracts, however, lowered the HDL level which was also exhibited by the standard drug, Orlistat.
Email: gvieve.cheung@gmail.com